Our Approach

We combine hormone testing, prescription medication, and physician guidance to help you optimize your health.

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Table of Contents
How it works 
Optimizing your dosage 
Enclomiphene Citrate vs Testosterone Replacement 
Clinical Studies 
Drug Facts 
Potential Side Effects 

How it works

Enclomiphene Citrate is a Selective Estrogen Receptor Modulator (SERM) that works by blocking estrogen receptors in the hypothalamus. This action increases the production of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), which in turn stimulates the testes to produce more testosterone naturally. Unlike exogenous testosterone, Enclomiphene helps maintain the body's natural hormone balance and fertility.

Optimizing your dosage

The optimal dosage of Enclomiphene Citrate varies from person to person. At Vital Protocol, we start with a standard dose of 6.5mg daily and adjust based on individual response. Regular blood tests and consultations with our healthcare providers ensure that your dosage is tailored to achieve optimal testosterone levels while minimizing potential side effects.

Clinical Studies

Testosterone Levels

Fig. 1 - Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement; PMID 26496621; DOI: 10.1111/bju.13337

Clinical trials have shown that Enclomiphene can increase total testosterone levels by 100-200% in hypogonadal men, bringing them well within the normal range (300-1000 ng/dL), without negatively impacting sperm production like TRT.

Sperm Concentration

Fig. 2 -  Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement; PMID 26496621; DOI: 10.1111/bju.13337

Unlike TRT, which can decrease sperm production by impairing LH and FSH production, Enclomiphene has been shown to maintain or even improve sperm concentration.

FSH/LH Levels

Fig. 3 - Earl JA, Kim ED. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism. Expert Review Endocrinology Metabolism; 2019;14(3):157-65

Enclomiphene works by helping your body naturally increase luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are necessary prerequisites for testosterone and sperm production. This stimulates your body to naturally produce more testosterone, without negative impacts on sperm production or testicular size. Testosterone replacement, on the other hand, may interfere with LH and FSH, resulting in lower sperm production and testicular shrinkage. 

Drug Facts

The optimal dosage of Enclomiphene Citrate varies from person to person. At Vital Protocol, we start with a standard dose of 6.5mg daily and adjust based on individual response. Regular blood tests and consultations with our healthcare providers ensure that your dosage is tailored to achieve optimal testosterone levels while minimizing potential side effects.

  • Generic Name: Enclomiphene Citrate
  • Drug Class: Selective Estrogen Receptor Modulator (SERM)
  • Route of Administration: Oral, once daily‍
  • Dosage Range: 6.5 mg - 25 mg (may vary based on individual needs)

Potential Side Effects

Enclomiphene has been extensively studied in phase II and phase III clinical trials, and is generally well tolerated. Side effects are relatively rare, but may include:

  • Headache
  • Nausea 
  • Hot flush 
  • Diarrhea
  • Joint pain 
  • Dizziness 

What's included:

At-home lab test or a referral to a lab closest to you
Personalized medication dosage and treatment plan for low testosterone
Telehealth appointment with a board-certified physician 
Access to your personal physician and treatment plan through our member portal 

Frequently asked questions

Everything you need to know about Vital Protocol.

Am I a good candidate for Enclomiphene?
If you're a biological male experiencing symptoms of low testosterone, such as low energy, low mood, reduced libido, difficulty building muscle, or trouble focusing, you may be a good candidate for Enclomiphene treatment. A lab test and consultation with one of our physicians will be the best way to determine if Enclomiphene is right for you. Start by taking our quick eligibility quiz here.
What is Enclomiphene?
Enclomiphene is a medication that helps stimulate your body's natural ability to produce testosterone. It is often used off-label to treat men with low testosterone, and has been clinically shown to double testosterone levels. Enclomiphene is taken as a once-daily pill, with the dosage decided upon based on your lab results and in coordination with one of our physicians.
When can I expect to see results?
You can typically expect to see results from Enclomiphene within a few weeks of starting treatment. However, full benefits may take a few months to show, as your body adjusts and testosterone levels gradually increase.
Does Enclomiphene have side effects?
Side effects of Enclomiphene are minimal, and the drug is generally well tolerated, with side effects occurring relatively rarely. Some known, but rare side effects include headache, nausea, joint pain, and dizziness. Our physicians will discuss potential risks and monitor your progress to ensure treatment is safe and effective for you.
How is this different from TRT?
Enclomiphene is different from Testosterone Replacement Therapy (TRT) in that it stimulates your body to produce its own testosterone rather than supplying synthetic testosterone. This approach can maintain natural hormone balance and avoid some side effects associated with TRT, such as testicular shrinkage and infertility.